New research has proven the sudden decline that a person feels at a certain age, noting that many molecules and microorganisms increase or decrease significantly between the ages of 44 and 60.

A team of scientists from Stanford University (USA) published their study in magazine Nature's agingHe evaluated thousands of different molecules in people aged 25 to 75, as well as their microbiomes — the bacteria, viruses and fungi that live inside the body and on the skin — and found that, for the most part, their abundances did not change gradually and chronologically.

In contrast, two periods of rapid change occur throughout life, on average at ages 44 and 60.

“We don’t just change gradually over time, there are actually radical changes. It turns out that age 40 is a time of radical changes, just like the beginning of the 60s,” said Michael Snyder, who is likely to have an impact on his health.

Stanford University highlighted in a statement that the number of molecules associated with cardiovascular disease showed significant changes in both cases, and those related to immune function changed in people aged 60 years.

Scientists used data from 108 people they followed to better understand the biology of aging.

Among other things, they found four different age profiles (aging patterns) that show that the kidneys, liver, metabolism and immune system age at different rates in each person.

The researchers analyzed biological samples every few months for several years, tracking thousands of different molecules, including RNA, proteins, and metabolites, as well as changes in the participants' microbiomes.

They observed that molecules and microbes showed changes in their abundance, increasing or decreasing. About 81 percent of all molecules studied showed nonlinear fluctuations in number, meaning they changed more at certain ages than at other times, from their 40s to their 60s.

The fact that so many radical changes occurred in the early 1960s may not come as a surprise, according to the Verge. Michael Snyder, it is well known that many risks for diseases and other age-related phenomena increase at this stage of life.

a surprise

The sheer number of changes in the mid-40s was surprising. At first, the scientists assumed that menopause or perimenopause caused major changes in women, skewing the entire group, but when they divided the study group by gender, they found that the change also occurred in men around age 40.

“This suggests that while menopause or perimenopause may contribute to the changes that occur in women in their 40s, there are likely other, more important factors that affect both men and women. Identifying and studying these factors should be a priority,” said the study’s lead author, Xiaotao Chen. Stanford University and also Nanyang Technological University, Singapore.

In people aged 40 years and older, significant changes were observed in the number of molecules associated with alcohol, caffeine and fat metabolism, cardiovascular disease, skin and muscle.